Research progress of D-dimer in the diagnosis of perioperative lower limb deep vein thrombosis in fracture

Abstract

Deep vein thrombosis is a disorder of venous return caused by abnormal intravascular coagulation, which has a high perioperative incidence in orthopedic patients and can develop into venous thrombosis syndrome and even fatal pulmonary embolism in severe cases. As a specific marker of thrombosis, D-dimer is widely used in diagnosing perioperative deep vein thrombosis in fractures, but its specificity in clinical diagnosis is low. It is often necessary to combine dynamic monitoring, ultrasound, Wells score, fibrinogen, and homocysteine to improve the accuracy of diagnosis. The authors have searched the literature and compiled a review of the latest research on D-dimer in diagnosing and managing deep vein thrombosis for clinical reference.