Abstract

Objective To explore the progress of cytotoxin-associated gene A (CagA) protein in the regulation of EMT(epithelial-mesenchymal transition) in cancer cells. Methods To review and summarize the domestic and foreign references related to CagA and EMT from CNKI, Wanfang database, Pubmed and Web of Science from January 1990 to January 2015, the keywords of Helicobacter pylori, CagA, gastric cancer cells, epithelial-mesenchymal transition in either English or Chinese were used. Results CgaA protein is delivered into epithelial cells via a type Ⅳ secretion system. In this process, CagA is not only associated with early cancer, but also binds to and activates/inactivates multiple signaling proteins, regulates different pathways included up-regulation of EMT-related transcription factors (Twist, Snail), repression of targeted mRNA by up-regulate miRNA related to growth and motility (miRNA-584, miRNA-1290, etc.), leads to EMT in cancer cells. Conclusions CagA may result in EMT in cancer cells with different pathways. Comprehensive research of these pathways will be beneficial for understanding the mechanism of invasion and metastasis of cancer. Key words: Gastric cancer; Epithelial-mesenchymal transition; Helicobacter pylori; Cytotoxin-associated gene A; Signal transduction

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