Research progress of ClC-3 in endometriosis

Abstract

Chloride Channel-3 (ClC-3) is a member of the Cl2 channel superfamily, which is encoded by CLCN3 gene. It involves regulating electrical activity, cell volume, proliferation, migration, invasion, apoptosis and intracellular pH, which have become a hot spot of current research. In recent years, the research of ClC-3 in gynecological diseases is increasing day by day. This article will review the research progress of ClC-3 and benign and malignant gynecological diseases, especially the relationship between ClC-3 and the occurrence and development of endometriosis. Key words: Endometriosis; Chloride channels; Cell movement; Review