Research progress of circulating melanoma cells in melanoma

Abstract

In recent years, the incidence of melanoma has increased rapidly worldwide. For the high malignancy and early metastasis of melanoma, many first-visit patients were diagnosed with distant metastasis and the tumor cannot be completely removed by surgery resection. Circulating melanoma cells are melanoma cells that enter the blood circulation from primary or metastatic lesions, playing an important role in tumor recurrence and metastasis. Previous studies have shown that testing for circulating melanoma cells by liquid biopsy can be used for early diagnosis, clinical staging, prognosis prediction and therapeutic evaluation, which have received extensive attention. This article reviewed the method of circulating melanoma cells detection and their related effects. Key words: Melanoma; Circulating tumor cell