Abstract
Circular RNA (circRNA) is a group of widely existed endogenous non-coding RNA. Its main structural feature is closed covalently cyclic loops and lack of the 5′-end, the 3′-end, and poly (A) tail, which resistant to degradation by RNA exonucleases and avoid debranching by adenylate debranching enzymes. Therefore, circRNA is stable in structure and function. Recent researches have revealed that circRNA mainly participates in transcriptional and posttranscriptional regulation, especially acts as microRNA (miRNA) sponge to regulate target gene expression as competitive endogenous RNA (ceRNA). circRNA is directly or indirectly involved in development of hematopoiesis in marrow and hematological malignancies, and is expected as a new diagnostic biomarker or molecular therapeutic target for hematological malignancies. In order to investigate relationships between circRNA and malignant transformation, therapeutic efficacy and prognosis of hematologic malignancies, this review summarizes the classification, characteristics, biological functions of circRNA and its role in hematopoiesis and hematologic malignancies. Key words: RNA, untranslated; microRNAs; Hematopoiesis; Hematologic neoplasms; Biological markers; circRNA
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