Abstract
As a product in the process of insulin synthesis, C-peptide’s physiological function is still not very clear. Recent studies have shown that C-peptide has many potential cell targets and has biological effects on a variety of tissue systems in humans and other animals. In this paper, the effects of C-peptide on diabetic complications, reproductive endocrine system, blood system, tissue repair, and neoplastic diseases were reviewed to provide references for further clarification of c-peptide related problems.
Highlights
C-peptide is a polypeptide composed of 31 amino acids; it is a key substance connecting proinsulin alpha chain and beta chain, and plays an important role in the correct folding of proinsulin and the formation of disulfide bonds
As a homologous active substance secreted by insulin, C-peptide has not been paid enough attention for a long time, and its physiological function is still not very clear
C-peptide was previously considered to be inert, but more and more studies have shown that C-peptide is a physiologically active molecule with many potential cellular targets [1]; it can play an important role in diabetic complications, reproductive endocrine system, blood system, tissue re
Summary
C-peptide is a polypeptide composed of 31 amino acids; it is a key substance connecting proinsulin alpha chain and beta chain, and plays an important role in the correct folding of proinsulin and the formation of disulfide bonds. The regulation of insulin on blood glucose, fat and protein metabolism has been very clear, and has long been used clinically as a hypoglycemic drug. As a homologous active substance secreted by insulin, C-peptide has not been paid enough attention for a long time, and its physiological function is still not very clear. C-peptide was previously considered to be inert, but more and more studies have shown that C-peptide is a physiologically active molecule with many potential cellular targets [1]; it can play an important role in diabetic complications, reproductive endocrine system, blood system, tissue re-.
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