Research Progress of Buyang Huanwu Decoction in the Treatment of Diabetic Peripheral Neuropathy

Abstract

Diabetes peripheral neuropathy is a complication aused by diabetes, involving peripheral nerves. The onset of DPN is occult and the process is slow, and the late stage of the disease will lead to severe nerve damage. With the change of modern people's lifestyle, the number of obese people is increasing, which leads to the increasing number of DPN patients. Common hypoglycemic drugs can not control blood sugar well and can not interfere with the process of DPN. Opioid analgesics and antiepileptic drugs are often used to relieve neuropathic pain and other symptoms in clinic. However, these drugs can only relieve the pain at that time, treat the symptoms but not the root cause, and have great toxic and side effects on human body. Therefore, the research and development of DPN specialty drugs has attracted wide attention around the world. Unfortunately, most of the drugs under research have failed due to safety problems. Therefore, there is an urgent need for safe and effective drugs to treat DPN. Therefore, it is necessary to treat this disease by means of traditional Chinese medicine. The Buyang Huanwu Decoction recorded in the medical forest correcting mistakes is a famous prescription for supplementing qi and activating blood circulation, which has the pathogenesis of DN. The research shows that the effect of Buyang Huanwu Decoction on DPN is accurate, but the effective substances and the mechanism of action in Buyang Huanwu Decoction are not clear. This subject takes Buyang Huanwu decoction as the research object to explore its mechanism of action and the research progress of clinical application, so as to lay a solid foundation for the treatment of diabetes peripheral neuropathy by traditional Chinese medicine. The Buyang Huanwu Decoction recorded in the medical forest correcting mistakes is a famous prescription for supplementing qi and activating blood circulation, which has the pathogenesis of DN. The research shows that the effect of Buyang Huanwu Decoction on DPN is accurate, but the effective substances and the mechanism of action in Buyang Huanwu Decoction are not clear. This subject takes Buyang Huanwu decoction as the research object to explore its mechanism of action and the research progress of clinical application, so as to lay a solid foundation for the treatment of diabetes peripheral neuropathy by traditional Chinese medicine.