Research progress of brain-derived microparticles on microglia polarization in radiation-induced brain injury of head and neck tumors

Abstract

Radiation brain injury（RBI） is one of the complications of radiotherapy for head and neck malignant tumors, which has a serious impact on the prognosis and quality of life of patients. The existence of radiation-induced brain injury not only limits the radiation therapy dose of head and neck malignant tumors, but also restricts the efficacy of tumor patients, and has a serious impact on the prognosis and quality of life of patients. The pathogenesis of radiation-induced brain injury is not yet completely clear, we use various clinical treatment for radiation brain injury patients to alleviate some clinical symptoms, but it cannot effectively reverse the brain injury process. In recent years, with the further exploration of radiation-induced brain injury and the accumulation of clinical experience, studies have found that microglial polarization plays an important role in radiation-induced brain injury, and brain-derived particles can activate microglia. This article reviews the research progress of brain-derived microparticles on the polarization of microglia in radiation-induced brain injury of head and neck tumors.