Abstract
Papillary thyroid cancer (PTC) is the most common pathological type of thyroid cancer, and its morbidity raises rapidly in the global world. V-raf murine sarcoma viral oncogene homolog B1 (BRAF)V600E mutation and telomerase reverse transcriptase (TERT) promoter mutations are the most common molecular markers of PTC. Nowadays, more and more studies find that the coexistence of BRAFV600E and TERT promoter mutations plays a synergistic role in the invasion and prognosis of PTC. This article reviews the recent advance in the synergism of BRAFV600E and TERT promoter mutations in PTC. Key words: Thyroid neoplasms; Mutation; Proto-oncogene proteins B-raf; Telomerase; Trends
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