Abstract
Aplastic anemia (AA) is considered as an immune-mediated bone marrow failure, but the specific pathogenesis is still under-researched. B lymphocyte-induced maturation protein (Blimp)-1 is a transcriptional repressor encoded by positive regulatory domain (PRDM)1 gene and is required to trigger the maturation of B lymphocytes into antibody secreting cells. Mounting evidence suggests that Blimp-1 plays a common role in the terminal differentiation of multiple T lymphocyte subsets, and functions significantly in the pathogenesis of many immune disorders. Here, we summarized the function of T lymphocytes in AA and the recent advances on the relationships of Blimp-1 and T lymphocytes, and we discuss the role of Blimp-1 regulating T lymphocytes in pathogenesis of AA. Key words: Blimp-1; T-lymphocytes; Anemia, aplastic; B lymphocyte-induced maturation protein-1
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