Research progress of B lymphocyte induced maturation protein-1 on regulation of differentiation and survival of plasma cells in multiple myeloma

Abstract

Multiple myeloma (MM) is an incurable plasma malignancy and currently the incidence goes up annually. There is one of feasible methods to explore new targets and strategies for the treatment of MM from the regulation of differentiation and survival of plasma cells. B lymphocyte induced maturation protein(Blimp)-1 is a key transcription factor to regulate differentiation and survival of plasma cells, but up to now, items of research articles on Blimp--1 mechanism in MM are very liffle. Related research has shown that myeloma cells highly expressed Blimp-1 and RNA interference silencing Blimp-1 expression eradicated plasma cell differentiation and made each kind of immunoglobulin (Ig) synthesis disorder, thus inhibiting myeloma cells proliferation and inducing its apoptosis. This review focused on the research progress of Blimp-1 on regulation of differentiation and survival of plasma cells in MM. Key words: Multiple myeloma; Plasma cells; Transcription factor; B lymphocyte induced maturation protein-1