Research Progress of Ascorbyl Palmitate in Drug Delivery and Cancer Therapy

Abstract

Cancer treatment continues to face formidable challenges, including the side effects associated with traditional treatment methods, cancer cell resistance, and the lack of specificity in existing therapeutic drugs. The anticancer properties of ascorbic acid (AA) offer new hope for cancer treatment. As a derivative of AA, ascorbyl palmitate (AP) inherits the antioxidative properties of AA and is even more stable. Additionally, AP's amphiphilic nature allows it to be utilized as a nanoliposome. This paper summarizes various modification approaches of AP within drug delivery platforms, revealing its promising role in cancer therapy. Specifically, AP can be employed to modify liposomes, enhancing the targeting and stability of existing cancer drugs while reducing their toxicity. Additionally, AP is thought to have the potential to function as a cancer vaccine platform. Despite its limitations, using AP to treat cancer offers a novel viewpoint on cutting-edge therapeutic approaches and propels the development of current therapeutic methods.