Abstract

Secreted frizzled related protein 5 (Sfrp5)is a member of the Sfrps family,as an inhibitor of the Wnt signal transduction pathway,which regulates the Wnt signal transduction pathway and affects embryonic development,cell proliferation and tumorigenesis.The latest researches show that Sfrp5 is a new adipokine.Expression of Sfrp5 is strongly increased when preadipocyte differentiates into mature adipocyte.Sfrp5 also can inhibit the Wnt signal transduction pathway of adipose tissue,promote adipocyte differentiation,increase diet induced obesity.The level of Sfrp5 is related to obesity and diabetes,which reduces noncanonical Wnt signal transduction pathway to improve insulin resistance.Further study of biological function of Sfrp5 may offer therapeutic opportunity for obesity and related metabolic disorders. Key words: Sfrp5 ; Non-classical Wnt signal pathway; Adipokine; Insulin Resistance

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