Abstract

间质-上皮细胞转化因子(mesenchymal-epithelial transition factor, MET)扩增是表皮生长因子受体(epidermal growth factor receptor, EGFR)阳性非小细胞肺癌(non-small cell lung cancer, NSCLC)耐药的重要驱动因素,MET-酪氨酸激酶抑制剂(tyrosine kinase inhibitors, TKIs)联合EGFR-TKIs的治疗策略可以克服MET介导的获得性耐药。研究表明,MET扩增也是间变性淋巴瘤激酶(anaplastic lymphoma kinase, ALK)、RET、ROS1等驱动基因阳性NSCLC患者接受TKIs类药物治疗后耐药的驱动因素。本文综述了近年来关于MET扩增作为驱动基因阳性NSCLC靶向治疗耐药驱动因素的研究进展,并总结了克服这种耐药机制的治疗策略。

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