Research progress in the role of inflammation in regulating adult hippocampal neurogenesis in cognitive decline of elderly patients

Abstract

The elderly patients often suffered from cognitive decline. Chronic inflammatory responses inhibit hippocampal neurogenesis, which is one of the important mechanisms of cognitive decline in the elderly patients. To provide insights for further study and new thoughts for prevention or treatment of cognitive decline in elderly patients, this article reviewed the research progresses on regulation of peripheral and central inflammation to hippocampal neurogenesis and their role in cognitive decline in elderly patients. Key words: Inflammation; Hippocampal; Neurogenesis; Aged; Cognition