Abstract
Breast cancer is a hormone-dependent tumor and estrogen plays an important role in its occurrence and development, while estrogen mediates through estrogen receptor (ER). ER is a nuclear transcriptional factor encoded by its genes, which includes two subtypes. Studies have shown that the absence or mutation of ERα expression is associated with poor prognosis of breast cancer, while the correlation between ERβ expression and breast cancer prognosis is different in vitro experiments and clinical studies. This article reviews the role of ERβ encapsulation, its subtype in the occurrence and development of breast cancer, its role in endocrine therapy and predictive value for breast cancer prognosis. Key words: Estrogen receptor alpha; Estrogen receptor beta; Breast neoplasms; Prognosis
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