Abstract
Neonatal purulent meningitis is one of the severe infectious diseases of the central nervous system.Escherichia coli K1(E.coli K1)strain is the most common Gram-negative bacteria which leads to neonatal purulent meningitis.The mechanism of E. coli K1 translocation of the blood-brain barrier(BBB)include the high degree of bacteremia, invasion of brain microvessel endothelia cell by E. coli K1, receptor-mediated pinocytosis transport for E. coli K1 and the living bacteria across the BBB.The current knowledge on the mechanisms underlying the successful E. coli K1 translocation of the BBB are summarized in this review. Key words: Purulent meningitis; Neonate; Escherichia coli K1; Blood-brain barrier; Mechanism
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