Abstract
The uridine diphosphate-glucuronosyl transferase 1A1 (UGT1A1) gene mutation can affect the expression of UGT1A1 gene and enzyme activity, and then reduce bilirubin metabolism leading to unconjugated hyperbi-lirubinemia.With the development of molecular biotechnology, more and more studies are trying to identify the pathogenesis of these polymorphisms by analyzing the expression and enzyme activity of UGT1A1 gene polymorphisms.Now, the progresses in the study of the expression of UGT1A1 gene polymorphism were reviewed. Key words: Uridine diphosphate-glucuronosyl transferase 1A1 gene; Polymorphism; Unconjugated hyperbi-lirubinemia; Enzyme activity
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