Abstract
Nucleic acid vaccine is a new type of vaccine,which can deliver foreign genes (DNA or RNA) encoding antigens of interest directly into animal cells,produce antigens through host cell expression system,and further induce immune response in the host.It is reported that nucleic acid vaccine is better than protein vaccine because it is immunogenic and safe,and easy to be modified and manufactured.In practical production,nucleic acid vaccine has many advantages,such as easy preparation and purification,short production cycle,low production cost,and easy to form multivalent vaccines.Therefore,it is hopeful that nucleic acid vaccine will become a successful vaccine for human use.This review summarizes research progress of nucleic acid vaccine. Key words: Vaccines, DNA ; Genes; Safety ; Immunogenicity
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