Research progress in mechanisms of mesenchymal stem cells on graft versus host disease

Abstract

Mesenchymal stem cells (MSC) are non-hematopoietic stem cells with self-renewal and multi-directional differentiation potential, and have low immunogenicity and immune regulation. After years of experiments and preclinical and clinical research experience, MSC are gradually becoming a treatment for preventing and alleviating graft-versus-host disease (GVHD). The characteristics, differentiation potential and surface markers of MSC have been studied in the past, and relevant clinical reports have also been proved that simultaneous infusion of MSC and hematopoietic stem cells (HSC) could promote HSC implantation and support hematopoiesis, as well as prevent and alleviate the occurrence of GVHD. However, the mechanisms are still unclear, so this article reviews the research progress of mechanisms of MSC in GVHD. In order to provide new ideas for the prevention, diagnosis and treatment of GVHD. Key words: Hematopoietic stem cell transplantation; Mesenchymal stem cells; Mesenchymal stem cell transplantation; Graft vs host disease; Immunotherapy; Immunomodulation; Allogeneic hematopoietic stem cell transplantation; Prevention