Abstract
The relationship between fibrosis and normal re pair are not understood. Acute injury may cause normal mesenchymal cells to convert to fibrogenic phenotype that may lead to fibrosis when inappropriately sustained. Crohn's disease (CD)associated fibrosis results from chronic transmu ral inflammation. Intestinal inflammation in CD is transmural, often associated with extracellular matrix changes, luminal narrowing and stricture formation. But the pathogenesis of stricture formation remains unclear. Current therapies do not alter its progression to intestinal fibrosis and obstruction. The aim of this review is to discuss the current understanding of fibrogenesis in CD.
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