Abstract
Many studies have shown that a small fraction of cells inside breast tumors possess the ability of self-renewal and differentiation; these cells are called breast cancer stem cells (BCSCs) and play a vital role in tumor progression and metastasis. The characteristics of BCSCs are regulated by multiple intracellular and extracellular factors, including some important signaling pathways (e.g., sonic hedgehog, Wnt, and Notch), transcription factors (e.g., Bmi-1), noncoding RNAs (e.g., miR-93 and miR-100 ), and cytokines (e.g., interleukin-6). In addition, the tumor microenvironment, including nontumor cells (e.g., mesenchymal stem cells and macrophages) and noncellular components (e.g., cytokines), is also a key factor regulating BCSCs. Because BCSCs are resistant to conventional therapies, these therapies may be more efficacious when used in combination with BCSC-targeted therapies. In this review, we focus on recent research progress regarding the regulation of BCSCs and BCSC-targeted therapies.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
