Abstract
The incidence of allergic diseases continues to rise. Cross-sectional and longitudinal studies have indicated that allergic diseases occur in a time-based order: from atopic dermatitis and food allergy in infancy to gradual development into allergic asthma and allergic rhinitis in childhood. This phenomenon is defined as the “atopic march”. Some scholars have suggested that the atopic march does not progress completely in a temporal pattern with genetic and environmental factors. Also, the mechanisms underlying the atopic march are incompletely understood. Nevertheless, the concept of the atopic march provides a new perspective for the mechanistic research, prediction, prevention, and treatment of atopic diseases. Here, we review the epidemiology, related diseases, mechanistic studies, and treatment strategies for the atopic march.
Highlights
In recent decades, the incidence of allergic diseases has continued to increase, affecting ∼20% of the worldwide population, especially children [1]
Cross-sectional and longitudinal studies have suggested that allergic diseases occur following a time-based order: from atopic dermatitis (AD) and food allergy in infancy to gradual development into allergic asthma (AA) and allergic rhinitis (AR) in childhood
Zhong et al found that the clinical symptoms and quality of life of AD patients with house dust mite (HDM) sensitization could be improved after 2 years of Allergen-specific immunotherapy (ASIT) [119]
Summary
Specialty section: This article was submitted to Immunological Tolerance and Regulation, a section of the journal Frontiers in Immunology. The incidence of allergic diseases continues to rise. Cross-sectional and longitudinal studies have indicated that allergic diseases occur in a time-based order: from atopic dermatitis and food allergy in infancy to gradual development into allergic asthma and allergic rhinitis in childhood. This phenomenon is defined as the “atopic march”. The mechanisms underlying the atopic march are incompletely understood. The concept of the atopic march provides a new perspective for the mechanistic research, prediction, prevention, and treatment of atopic diseases. We review the epidemiology, related diseases, mechanistic studies, and treatment strategies for the atopic march
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