Abstract
The mechanism of the anti-reabsorptive ability of bisphosphonates has been well elucidated and by now bisphosphonates become standard treatment for preventing skeletal complications associated with bone metastases. An increasing number of in vivo and vitro preeJinical trial have indicated that bisphosphonates including zoledronie acid exert anti-tumor effects by inhibiting the proliferation, adhesion and invasion of tumor cells, besides inhibiting angiogensis and modulating immune response. Also evidences of synergistic anti-tumor effects are found when zoledronic acid combines with chemotherapy and radiotherapy. Key words: Diphosphonates; Imidazoles; Antineoplastic agents
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
