Research on traditional Chinese medicine syndrome factors in cognitive disorder after apoplexy based on TCMISS

Abstract

Objective The purpose of this research is to analyze TCM syndrome factors in cognitive disorder after apoplexy, provide evidence for etiology and pathogenesis as well as syndrome differentiation and treatment. Methods The research analyzed 838 patients with mild cognitive disorder and 613 patients with mild dementia. Those patients were selected by multi-centered cooperation method. And symptoms of those patients were selected by frequency equal or greater than 10 percent. After inputting normalized information of the four methods of diagnosis into TCMISS, rule of symptoms was analyzed by TCMISS which provided data mining methods in Chinese medicine. Results Using entropy partition method which provided by TCMISS, 8 collective symptoms groups were found in mild cognitive disorder while 9 collective symptoms groups were found in mild dementia, and the groups of syndrome factors could be extracted as deficiency of the kidney, qi deficiency and blood stasis, spleen and kidney deficiency, stagnation of endogenous retention of phlegm; deficiency of the kidney, stagnation of endogenous retention of phlegm, qi deficiency and blood stasis, spleen and kidney deficiency, stagnation of endogenous retention of phlegm, fire excess from yin deficiency. Conclusion The syndrome factors of cognitive disorder after apoplexy are deficiency of qi, blood stasis, sputum, deficiency of yang, deficiency of yin and fire. And disease is located in brain, involving kidney, liver, and spleen mainly. The characters of the disease are real, mixing others. And typical syndromes in cognitive disorder after apoplexy are: deficiency of the kidney, qi deficiency and blood stasis, spleen and kidney deficiency, stagnation of endogenous retention of phlegm and fire excess from yin deficiency. Fire excess from yin deficiency becomes serious and prominent, followed by the ill aggravation.