Research on the risk factors of prognosis of medullary gliomas microsurgery in children

Abstract

Objective To evaluate the risk factors of prognosis of medullary gliomas microsurgery in children. Methods The clinical data of 32 children with medullary glioma who underwent microsurgery in Jiaozhou People’s Hospital from January 2015 to December 2016 were retrospectively analyzed. Postoperative survival time, prognosis, causes of death and tumor recurrence condition were followed up and recorded. Results Of the 32 children, total resection was performed in 7 cases, subtotal resection in 15 cases and partial resection in 10 cases. All children were diagnosed as medullary gliomas according to pathology, including 2 cases of World Health Organization (WHO) grade Ⅰ, 21 cases of WHO grade Ⅱ, 5 cases of WHO grade Ⅲ, 4 cases of WHO grade Ⅳ. Postoperative follow-up showed that the 1-year survival rate was 75.0% (24/32) and the 5-year survival rate was 62.5% (20/32) in children. The mean survival time for all children was (70.5±10.8) months. Multivariate Cox analysis showed that tumor resection degree (RR=12.409, 95% CI: 1.362-113.151, P=0.027) and WHO classification of tumor pathology (RR=128.614, 95% CI: 2.366-6 885.171, P=0.018) were independent risk factors of the prognosis of children with medullary gliomas. Conclusions The children with medullary glioma in lower pathologic grade is more. Tumor resection and tumor WHO staging are independent risk factors for the prognosis of children. Key words: Children; Glioma; Medulla oblongata