Research on the protection and mechanism of coptis alkaloids on acetic acid type gastric ulcer

Abstract

This paper studied the therapeutic effect of Coptis alkaloids on acetic acid type gastric ulcer and its possible mechanism. Acetic acid type gastric ulcer model is used and administered for 7 days, and the rats are killed, and then IPP software is used to calculate the area of ulcer of gastric tissue and the inhibition rate of ulcer. ELISA kit is also used to measure the expression level of epidermal growth factor (EGF) in serum of rats, 5-hydroxytryptamine (5-HT) in brain and noradrenaline (NE) in adrenal tissue. At the same time, HE staining is used to observe the healing state of gastric tissue. The experiment result shows that the ulcer area of Coptis total alkaloids group 25 mg/kg/day is significantly lower than that of the model group (P < 0.01), and the inhibition rate of ulcer is more than 50%; at the same time, it increases the content of EGF in serum (P < 0.05), promotes the healing of injured gastric tissue; and it also significantly increases 5-HT content in brain tissue and NE content in adrenal tissue (P < 0.01, P < 0.01), and to some extent, it regulates the mood of rats and prevents the recurrence of ulcer; the HE staining results shows that the Coptis total alkaloids promotes the recovery of gastric injury. Therefore, the Coptis total alkaloids can promote the healing of acetic acid type gastric ulcer, and its mechanism may be that it improves the healing quality of gastric ulcer by regulating the emotion of rats, which results in the effect of treating gastric ulcer.