Research on the preparation and characterization of chitosan grafted polyvinylpyrrolidone gel membrane with iodine

Abstract

ABSTRACTThe chitosan grafted polyvinylpyrrolidone gel membrane with iodine (CS‐PVP‐I2‐G‐M) was prepared by chitosan–polyvinylpyrrolidone–iodine complex liquid (CS‐PVP‐I2‐L) mixed with gelatin. The intermediate product CS‐PVP‐I2‐L was prepared by CS grafted PVP in the protection of N2 with dimethyl 2,2′‐azobis (2‐methylpropionate) (AIBME) as initiator, then a certain amounts of iodine in ethanol solution was added. The properties of CS‐PVP‐I2‐G‐M were characterized by IR, UV–Vis, SEM, XRD, DSC, and so forth. The iodine release results coherent with the release kinetic model—Fick diffusion laws, has a burst effect first, and then spread, and the emission of iodine was maintained within a certain range and kept at a stable level permanently, showed a sustained‐release effect of iodine. The inhibition zone diameters of CS‐PVP‐I2‐G‐M against Staphylococcus aureus and Escherichia coli were both greater than 16 mm, it demonstrated significant antibacterial activity. Double effects sustained‐release effect of iodine and the significant antibacterial activity made CS‐PVP‐I2‐G‐M highly potential for applications as a novel natural biomedical sterilization materials. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41797.