Abstract
Mechanical environment plays an important role in the growth of cells, tissues and organs, in the study of mechanobiology and tissue engineering, and loading bioreactor acts as the basic platform. We developed a combined multi-functional bioreactor based on linear motor, and studied on the loading performance of different modules and loading methods. In the rolling / sliding loading module, in the effective distance for 50mm case, the bioreactor frequency is 0.01Hz to 0.3Hz. Under tensile and compressive loading module, the minimum amplitude of the bioreactor can reached 0.01mm while the frequency can reach 10Hz. Under the impact test module, in the effective distance for 50mm case, acceleration a=54.16m/s2 can be realized. In the high acceleration cyclic loading module, acceleration 8Gcan be realized. The combined multi-functional bioreactor provides conditions for the study related mechanobiology and tissue engineering.
Highlights
At present, there is a big challenge to repair the defect of human body tissue
Tissue engineering is an ideal method for repairing the tissue defect
Tissue engineering need to construct artificial tissue in vitro, and bioreactor plays a crucial role in tissue engineering, They can be constructed on the cell scaffold in a controllable mechanical environment, even large-scale industrial production [1]
Summary
Tissue engineering is an ideal method for repairing the tissue defect. Tissue engineering need to construct artificial tissue in vitro, and bioreactor plays a crucial role in tissue engineering, They can be constructed on the cell scaffold in a controllable mechanical environment, even large-scale industrial production [1]. The ability of accurately simulated tissue, organ and cell mechanics environment is the focus of attention, and each tissue type (such as skin, bone, blood vessel, and cartilage) may require designing the different bioreactor [2]. Cartilage tissue engineering bioreactor mainly types includes mechanical stirring bioreactor, perfusion - hydraulic type bioreactor, rotating wall bioreactor, air lift bioreactor, micro load type bioreactor and other bioreactor. This paper conducted a deep study of the combined multi-functional bioreactor based on linear motor. Provided references for mechanical biology and tissue engineering experiment, and determined the suitable frequency, amplitude and maximum acceleration of the bioreactor. According to the main modules of the loading platform, study on the loading performance from the following aspects
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