Research on the pharmacokinetic interaction between components of quick-acting anti-motion capsule

Abstract

Objective To study the pharmacokinetics of the quick-acting anti-motion capsules with a single dose in beagle dogs and its interaction,when combined with other drugs.Methods Six adult healthy Beagle dogs were randomly divided into 3 groups,each consisting of 2.The tri-preaparatum and tri-periodicity Latin square method was used in the experiment.During the first phase of the experiment,the animals of the 3groups were respectively administered the quick-acting anti-motion capsule and the control drugsdimenhydrinate and dextroamphetamine sulfate.During the second phase of the experiment,all the animals of the 3 groups were respectively given dimenhydrinate,dextroamphetamine sulfate and the quick-acting antimotion capsule.During the third phase of the experiment,the animals of the 3 groups were respectively given dextroamphetamine sulfate, the quick-acting anti-motion capsule and dimenhydrinate. Level of dextroamphetamine sulfate and dimenhydrimate in the serum were measured with LC/MS/MS.Through the access of pre-clinical pharmacokinetics studies,we estimated relative bioavailability and main the quick-acting anti-motion capsule pharmacokinetic parameters of,as characterized by dextroamphetamine sulfate and dimenhydrimate.Results No significant differences could be seen in the pharmacokinetic parameters including tmax 、lnCmax 、lnAUC0-24 following oral administration of a single dose of quick-acting anti-motion capsule and dextroamphetamine(P ＞ 0.05).Two one-sided t tests of the lnCmax and lnAUCo-24 indicated that the pharmacokinetic parameters of dextroamphetamine sulfate combined with dimenhydrimate and the ginger extract (quick-acting anti-motion capsule) do not change distinctly,when compared with those of dimenhydrimate (P ＞ 0.05 ).Conclusions No significant pharmacokinetic interaction could be noticed,when the components of the ginger extract (quick-acting anti-motion capsules ) were combined with dimenhydrimate and Dextroamphetamine sulfate. Key words: Quick-acting anti-motion capsules; Pharmacokinetics; Dextroamphetamine sulfate; Dimenhydrimate; Interaction