Research on the performance of PGS/PLLA electrostatic spinning of composite nanofiber scaffold

Abstract

A novel electrospinning scaffold material of poly glycerol-sebacate/poly-L-lactic acid (PGS/PLLA) was prepared. The 25% spinning solutions were prepared with mass ratios of PGS and PLLA of 1:3, 1:1 and 3:1 respectively, taking hexafluoroisopropanol (HFIP) as the solvent. Scaffold material was characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction(XRD), thermogravimetry (TG), Instron testing machine, and water contact angle (WCA) analysis. SEM observation showed that the electrospinning material had uniform, interwoven network structure. FT-IR and XRD analysis indicated that the addition of PLLA had little impact on the structure of PGS polymer and the crystallinity of scaffold material increased with the increasing of PGS level. TG reported that PLLA increased thermal stability of the PGS/PLLA co-electrospun material. WCA analysis indicated good hydrophilic property and the tensile testing showed excellent mechanical pro-perty. Biological experiment under co-cultured goat temporomandibular joint disc cells with PGS/PLLA scaffold indicated that the cells presented a favorable adhesion and proliferation on the optimized three dimensional PGS/PLLA(1/3 group) scaffold. © 2016, Materials Review Magazine. All right reserved.