Abstract
Epilepsy is a group of chronic brain diseases characterized by transient central nervous system dysfunction caused by repeated abnormal synchronization of neuronal discharges in the brain, with sudden onset and repeated seizures. Epilepsy has been listed as one of the five major neuropsychiatric diseases of the World Health Organization (WHO). Hereditary epilepsy refers to epilepsy syndromes previously classified as idiopathic generalized epilepsies (IGEs), which encompasses several different epilepsy syndromes ranging in clinical severity from relatively benign febrile convulsions (FS) and childhood absence epilepsy (CAE) to the more severe juvenile myoclonic epilepsy (JME) and generalized epileptic seizures with febrile convulsions (GEFS+). This article analyzes the direction of ion channel related to epileptic seizures. It will look forward to the future research direction of some of the ion channels related to epileptogenesis.
Highlights
The causes of epilepsy are complex, and what exactly happens to the brain during epileptogenesis is epilepsy is a hot topic of recent research
Much progress has been made in human research on epilepsy and ion channels, but there is still a long way to go to clarify the molecular mechanism of epileptogenesis and to prepare precise drugs for epilepsy
The above results and discussion can demonstrate a potential link between alterations in Hyperpolarization-activated cyclic nucleotide-gated ion channels (HCNs) channels and Ih current-related functions and the development of epilepsy, but it is undeniable that the current study has not yielded results to prove that the absence or absence of functions of HCN channels that regulate cellular excitability can directly lead to seizures
Summary
The causes of epilepsy are complex, and what exactly happens to the brain during epileptogenesis is epilepsy is a hot topic of recent research. Ion channels are important physiological components related to the occurrence of neuronal excitations, usually consisting of several subunits, accompanied by the binding of auxiliary groups to complete their physiological properties. The complex composition of subunits and the variety of auxiliary groups regulate the excitation and inhibition of neurons, and their functional impairment may be one of the important factors leading to epilepsy. Much progress has been made in human research on epilepsy and ion channels, but there is still a long way to go to clarify the molecular mechanism of epileptogenesis and to prepare precise drugs for epilepsy. This article will look forward to the future research direction of some of the ion channels related to epileptogenesis
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