RESEARCH ON THE DEVELOPMENT OF ME DICINE BASED ON NATURAL COMPOUNDS

Abstract

The relevance of the search for effective hypoglycemic drugs is undeniable, due to the growth of patients with diabetes mellitus, accompanied by various diabetic complications. The purpose of the studies was to develop the composition, methods of analysis, quality standards with hypoglycemic and detoxifying effects. Developed drug includes total preparation of inulin and pectin and taurine. Qualitative analysis was carried out on the identification of pectoinline and taurine. To detect pectoinulin, the total preparation of inulin and pectin, color reactions were used (with a solution of α-naphthol alcohol 20% and with a solution of carbazole alcohol 0.5%), as well as a precipitation reaction with a solution of lead (II) acetate of the main 10%. To detect taurine, a color reaction with ninhydrin was used. The chosen procedures make it possible to establish the authenticity of taurine in the composition of the proposed drug in the joint presence of ingredients. The quantitative determination of inulin was carried out by the Bertran titrimetric method in the Maken and Shoorl modifications. Quantitative determination of pectin is proposed to be carried out by calcium-pectate method. Spectrophotometric method is proposed for determination of taurine in composition. The proposed methods of identification and quantitative determination of the ingredients of the composition are valid according to the main criteria. The studies made it possible to propose drug quality standards that are included in the draft regulatory documentation for the drug. As a result of all the conducted studies, the composition was developed and the optimal methods of qualitative and quantitative analysis of the ingredients of the proposed drug were selected, which make it possible to determine them in the joint presence, which are included in the draft pharmacopoeia article of the enterprise.