Abstract
Aim. Development of technology of dental gel with combined composition, establishment of optimal technological parameters for the introduction of active and auxiliary substances.Methods. After production of experimental gel, we determined homogeneity for the samples with the method of SPhU 1.1, section 511. The particle size of the suspension was studied using a XY-B2TLED microscope under polarized light according to SPhU 2.9.37. The quantitative determination of metronidazole benzoate and the accompanying impurities A, B, C, miramistin, sodium hyaluronate was performed by liquid chromatography, according to SPhU section 2.2.29, section 2.2.46.Results. According to the results of chemical and microscopic studies, the optimal method of introducing metronidazole benzoate into the gel base is the suspension method. To ensure the best distribution of metronidazole benzoate, a micronized substance was used and the technological parameters of pre-homogenization of metronidazole benzoate in propylene glycol at 20-25 °C were determined. Microphotographs of the gel samples showed that homogenization of metronidazole benzoate with propylene glycol at a speed of 3000 to 4000 rpm provides a homogeneous translucent gel of white colour. Selected methods of dissolution and technological parameters allow to obtain a stable gel without degradation products of active substances.Conclusions. The optimal way of introducing into the gel base the combination of active substances: metronidazole benzoate, myramistine, hyaluronate sodium is substantiated. The rational technology of production of the combined dental gel is developed. Critical stages and parameters of technological process are defined, criteria of their acceptability are established
Highlights
Inflammation and pain are associated with many diseases of the periodontal and oral mucous membranes develop with any traumatic effect on the mucous membrane [1]
Results of the research From a biopharmaceutical point of view, the most optimal is the presence of an active pharmaceutical ingredients (APIs) in the finished dosage form in solution form
We have studied the solubility of metronidazole benzoate, sodium salt of hyaluronic acid and miramistin in water and hydrophilic non-aqueous solvents [12]
Summary
Inflammation and pain are associated with many diseases of the periodontal and oral mucous membranes (periodontitis, gingivitis, stomatitis, red plaque, multiform exudative erythema, herpes, etc.) develop with any traumatic effect on the mucous membrane [1]. Solutions and liquids are often used to accelerate the regeneration and epithelialization of erosive ulcers in the oral mucosa. The special properties of gels (the combination of solids and liquids, hydrophilicity) make them a new generation of dentistry. They can be kept on the surface of the mucous membrane for a long time, providing its treatment with a medicinal substance [4, 5]. Gel form allows you to apply and keep the drug on the gums, in the gums or pockets, that is, on a specific area where it realizes its antibacterial, anti-inflammatory effect, contributes to the termination of bleeding gums. A clear tendency of modern dental practice is the use of metronidazole in combination with other drugs - antiseptic, antiinflammatory, reparative action [6, 7]
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