Abstract
Objective: This paper summarises the application characteristics of engineering technology and biological in preventing and treating sports cartilage injury. Methods: Using articular cartilage, engineering technology, biological materials as the Chinese keywords, and tissue engineering, cartilage, scaffold as the English keywords, the Pubmed database (http://www.ncbi.nlm) was searched by computer .nih.gov/PubMed) and the related articles of the Vip database (http://www.cqvip.com/) 1993-01/2010-10, excluding duplicate research or meta-analysis articles. Based on 23 articles, the focus is on the discussion of seed cells, scaffold materials, cytokines and their properties in repairing sports cartilage injury. Results: More than 104 documents were obtained from the initial computer examination. According to the inclusion and exclusion criteria, the seed cells, bioscaffold and cytokines used in engineering cartilage were summarised and analysed. Seed cells are the primary factor restricting the further clinical application of engineering cartilage. Currently used seed cells are chondrocytes, bone marrow stromal stem cells and embryonic stem cells; bioscaffold include natural and synthetic degradable polymers; the growth factors of engineering used for cartilage mainly include transforming growth factor, bone morphogenetic protein, fibroblast growth factor, insulin-like growth factor and so on. Conclusion: So far, no matter whether it is seed cells, scaffold materials, culture environment, etc. of engineering cartilage, no one material is considered to be the most ideal, and seeking a engineered cartilage with good performance is the focus of future research. However, many studies are still in the experimental stage, and there are still some problems to be solved, especially after the engineering cell scaffold material is implanted into the body, whether the degradation of the material is synchronised with the function of the cell, will there be genetic material changes, gene expression or genetic mutations and other issues, the application of it to the clinical needs of the relevant scholars and experts will continue to be practised and explored.
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