Abstract
In this paper, the surface of molybdenum disulfide nanosheets synthesized by hydrothermal method was modified with bovine serum albumin (BSA) and nucleic acid aptamers in order to construct a photothermal system with high target recognition, stable size, good biocompatibility and low toxicity Nano material molybdenum disulfide; Under 808 nm laser irradiation, suitable functionalized molybdenum disulfide nanosheets can produce singlet oxygen at an effective concentration for photodynamic therapy, and at the same time, photothermal therapy can also be used to achieve synergistic therapy and the therapeutic effect is more excellent. This shows that such functionalized molybdenum disulfide nanosheets have excellent therapeutic effect and great potential in tumor treatment.
Highlights
Cancer is one of the diseases with the highest morbidity and mortality in the world, and photothermal therapy is a new type of treatment [1,2,3,4]
The photothermal treatment process is accompanied by singlet oxygen production and damage to cellular mitochondria, which in turn causes rapid apoptosis of tumor cells; Experiments have proved that MoS2-bovine serum albumin (BSA)-Apt nanosheets have specific recognition of target cells, low toxicity, good biocompatibility and photothermal properties, and they are expected to be used in tumor precise treatment
From TEM image 2(a), it can be seen that the morphology of MoS2-BSA-Apt nanometer tablets is not strong, and the size is in the range of 100nm-150nm, which is a layer structure
Summary
Cancer is one of the diseases with the highest morbidity and mortality in the world, and photothermal therapy is a new type of treatment [1,2,3,4]. This article will develop a targeted functionalized molybdenum disulfide nanosheet that can be highly specific Molybdenum disulfide nanosheets are effectively enriched in tumor tissue to improve the treatment efficiency. This article will use the hydrothermal method and the assisted ultrasonic stripping method to construct the MoS2-BSA nanometer.After the aptamer was coupled to MoS2-BSA,MoS2-BSA withsmall size, temperature-temperature reduction, suspension stability, and near-infrared absorption characteristics and good photothermal temperature rise effect was prepared. The photothermal treatment process is accompanied by singlet oxygen production and damage to cellular mitochondria, which in turn causes rapid apoptosis of tumor cells; Experiments have proved that MoS2-BSA-Apt nanosheets have specific recognition of target cells, low toxicity, good biocompatibility and photothermal properties, and they are expected to be used in tumor precise treatment
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