Research on Polyethylene Glycol, Crosslinked Polyethylene Glycol & Polyethylene Glycol Chitosan Conjugate Coating for Biomedical Application

Abstract

Polyethylene glycol used as coating materials because it resist to protein adsorption and bacterial adhesion. Polyethylene glycol and crosslinked polyethylene glycol & polyethylene glycol chitosan conjugate used for coating glass implants. Fourier transform infrared spectroscopy (FTIR) analysis showed proper crosslinking in crosslinked polyethylene glycol but in polyethylene glycol & chitosan conjugate no reaction takes place. Scanned Electron Microscope (SEM) used for study of surface morphology. Polyethylene glycol & chitosan conjugate have smoother surface than pure polyethylene glycol, polyethylene glycol chitosan conjugate. Differential scanning calorimetry (DSC) analysis used for glass transition temperature study. Crosslinked polyethylene glycol has good mechanical properties. Antimicrobial properties of polyethylene glycol chitosan conjugate are good in comparison to pure polyethylene glycol, crosslinked polyethylene glycol.