Abstract
Cell photoacoustic detection faces the problem where the strength of the sound wave signal is so weak that it easily gets interfered by other acoustic signals. A sonic triode model based on an artificial periodic structure is designed by COMSOL Multiphysics 5.3a software (Stockholm, Sweden), and software simulations are conducted. Experiments show that when a sound wave with a specific frequency is input by the sound wave triode, it can produce an energy amplification effect on the sound wave signals of the same frequency and a blocking effect on the sound wave signals of other frequencies. This contrast effect is more obvious after increasing the sound pressure intensity of the input sound wave signal. It can effectively filter out interference sound signals. The study of the acoustic triode model provides a new approach for the acquisition and identification of acoustic signals in cell photoacoustic detection, which can significantly improve the working efficiency and accuracy of cell photoacoustic detection.
Highlights
Cell photoacoustic detection faces the problem where the strength of the sound wave signal is so weak that it gets interfered by other acoustic signals
In cell photoacoustic detection, an important factor limiting its development is the effective acquisition of high-frequency acoustic signals
Cell photoacoustic detection refers to the use of high-energy laser pulses to stimulate cells and cause them to expand thermally, thereby generating ultrasonic waves of a specific frequency
Summary
The collection of high-frequency acoustic signals has always been the focus of attention in modern medical activities. In cell photoacoustic detection, an important factor limiting its development is the effective acquisition of high-frequency acoustic signals. Cell photoacoustic detection refers to the use of high-energy laser pulses to stimulate cells and cause them to expand thermally, thereby generating ultrasonic waves of a specific frequency. The characteristics of cells can be analyzed by collecting ultrasound signals. They are different from the characteristics of ultrasonic waves produced by different cells, and at present, cell photoacoustic detection is widely used in tumor examination. Qian et al proposed a guided surgery method based on photoacoustic imaging to achieve tumor resection [5]. Lu et al proposed a photoacoustic contrast agent based on functional peptide-modified gold nanoparticles for the problems of the photoacoustic imaging of bacterial infections [6]
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