Abstract
Long-chain non-coding RNA HOXA11 antisense RNA (HOXA11-AS) is a kind of lncRNA discovered in recent years. Long-chain non-coding RNA (LncRNA) is an important regulatory factor of protein-coding genes, especially the disorder of LncRNA in more and more diseases which are found, including cancer. HOXA11-AS was first discovered in mouse embryo cDNA library using probes, and then it was discovered by scholars and played an important role in human cervical cancer, gastric cancer, glioma and other malignant tumor cells. Overexpression of HOXA11-AS has been found to promote cell proliferation, migration and tumor invasion, and has a carcinogenic effect. HOXA11-AS can promote tumor proliferation, metastasis and other malignant biological behaviors by interacting with miRNA and EZH2 protein, and is considered to be carcinogenic lncRNA. The discovery of HOXA11-AS provides new ideas for tumor prevention and treatment.
Highlights
In 1995, Potter et al found that the antisense strand of HOXAll can encode multiple transcripts when studying the effect of HOXAll gene on mouse fertility function [1]
Wang et al [34] used gene chip detection and found that the expression of HOXAll-AS in human glioma tissue was significantly increased, which was closely related to the grade and poor prognosis of glioma; multivariate Cox regression analysis showed that HOXA11-AS was more An independent prognostic factor for glioblastoma, its expression level is related to the molecular subtype of glioma in the tumor genome map; functional experiments have shown that overexpression of HOXA11-AS promotes cell proliferation, while interference with HOXA11-AS regulates cell cycle And inhibit cell proliferation
Yu et al [40] found that the expression level of HOXA11-AS in liver cancer tissues (40 pairs) and cell lines (HepG2, Hep3B, and MHCC.97H) was relative to that of adjacent tissues and normal liver epithelial cell lines ( L02) is significantly higher, HOXAll-AS inhibits the proliferation of liver cancer cells, promotes apoptosis, and delays the development of the cell cycle from G1 to GO phase; in terms of pathways, HOXAll-AS inhibits the expression of LATS1 by recruiting EZH2
Summary
In 1995, Potter et al found that the antisense strand of HOXAll can encode multiple transcripts when studying the effect of HOXAll gene on mouse fertility function [1]. In the past ten years, more and more studies have shown that lncRNA has very important biological functions in tumors and non-tumor diseases, and can regulate many pathophysiological pro-. Long et al [5] found that IncRNA Tugl is significantly low expressed in podocytes in diabetic mice, lncRNA-Tugl binds to the specific binding site upstream of the Ppargcla gene, enhances promoter activity, and promotes peroxisome proliferation without activation of receptor r (PPARr). A large number of studies have shown that the expression level of HOXA11-AS in tumor tissues is significantly increased, and it has the effect of promoting tumor occurrence and development: but there are a few reports showing that HOXA11-AS exhibits low expression in some tumor tissues, which can inhibit The function of tumor development [6]. This article reviews the existing research on HOXA11-AS, and provides references for further research on the relationship between HOXA11-AS and malignant tumors
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