Abstract
Second, we need a better understanding of the causes of cancer-related fatigue. Until we possess that information, attempts to prevent and treat fatigue will not be most effective because our interventions cannot be directed toward the causes. Biological markers of fatigue are also needed. This means more laboratory and clinical physiologic research and more objective measures of outcomes. The research team is moving in this direction with the use of actigraphy to measure sleep and activity levels in subjects. Third, more intervention-testing research is needed to provide the evidence-based clinical practice guidelines that offer the best hope for managing this clinical problem. The Pediatric Cooperative Group provides a structure for multisite clinical trials in which this intervention-testing research can be conducted. SUMMARY
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