Research on Endometrial Cancer: Risk factors, Classification and Treatment

Abstract

Endometrial cancer (EC) is one of the most common tumors of the female reproductive system. Its pathogenesis is complex, and the incidence tends to be younger, which seriously endangers women's health. Research has found that the calssification of EC is of great significance in clinical applications, including traditional types I (estrogen-dependent) and II (non-estrogen-dependent), as well as four molecular subtypes (POLE ultramutated, microsatellite instability hypermutated, copy number low, and copy number high). The risk factors affecting EC include genetic factors, obesity, menstrual irregularities, etc. In addition, significant progress has been made in the treatment of EC, with new breakthroughs in surgery, radiotherapy, chemotherapy, endocrine therapy, targeted therapy, etc. This article discusses risk factors, traditional classification, molecular classification and treatments of EC, in order to provide reference for clinical research on EC.