Abstract
The solubility information and dissolution mechanism of drugs in mixtures is significant in chemistry and pharmaceutical domains. The equilibrium saturated solubility of actarit in methanol + water, ethanol + water, 2-propanol + water and acetone + water in the temperature scope of 278.15–318.15 K was determined by using isothermal saturation method. The discussion of solvent effect, Hansen solubility parameters (HSPs), preferential solvation, thermodynamics and data correlation were performed. The solubility of actarit in mole fraction enhances as the increasing of temperature and mass fraction of alcohols in three alcohols-water mixtures, however, the solubility shown a cosolvency phenomenon at w = 0.80 in acetone + water mixtures. The solubility behavior and cosolvency phenomenon in actarit dissolution was discussed by HSPs in depth. The molecular interactions in solution were analyzed by KAT-LSER model of solvent effect. Furthermore, the preferential solvation mechanism of actarit in aqueous was obtained by IKBI method. In addition, the classical Jouyban-Acree model, Apelbat-Jouyban-Acree model and Van’t Hoff-Jouyban-Acree model were used to correlate the solubility data of actarit in four aqueous mixtures. The relative average deviation and root-mean-square deviation were used to evaluate the applicability of models. Finally, the apparent thermodynamics properties were calculated by Van’t Hoff analysis.
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