Abstract
In the biomedicine research domain, some accurate molecular analysis methods are limited if the input DNA, RNA, or protein is not derived from pure population of cells or is contaminated by the wrong cells. A novel piezo-power microdissection system using ultrasonic vibration was proposed to procure pure population of targeted cells from tissue sections for subsequent analysis. The principle of the ultrasonic vibration cutting is analyzed, and the piezo-power microdissection tool and the vacuum gripper are designed. A multilayer piezoelectric actuator is used to actuate a sharp needle vibrating with high frequency and low amplitude (Approx. 16-50 kHz, and 0-3 mum) to cut the tissue. A vacuum-capture gripper was designed to collect and transport the isolated target cells/tissue by using a close-loop system to control the working pressure. Experimental results showed that the embedded tissue can be quickly and precisely cut. Contrast experiment was done to test the feasibility of this bio-microdissection system
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