Abstract
The study is aimed at studying the association between the levels of serum adiponectin (ADPN), high-sensitivity C-reactive protein (hs-CRP), and soluble intercellular adhesion molecule-1 (sICAM-1) and hypertensive cerebrovascular complications. 50 patients with hypertensive cerebrovascular disease treated in Gansu Provincial Hospital from December 2016 to December 2018 were selected as the experimental group, and 50 normal people who underwent physical examination were selected as the control group. The blood pressure, heart rate, and the complications were recorded, and the serum blood lipid indexes were detected. Moreover, the content of serum ADPN, hs-CRP, and sICAM-1; the neurological indexes; brain-derived neurotrophic factor (BNDF); and neurone-specific enolase (NSE) were also determined using ELISA. The content of aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood urea nitrogen (BUN), and serum creatinine (SCR) in the experimental group was significantly higher than that in control group (p < 0.05); the incidence of cerebrovascular complications, systolic blood pressure, diastolic blood pressure, and heart rate increased (p < 0.05); the content of total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), hs-CRP, and sICAM-1 obviously rose (p < 0.05); and the content of ADPN and HDL obviously declined (p < 0.05). Besides, the experimental group had evidently lower systolic blood flow velocity (Vs), diastolic blood flow velocity (Vd), and mean blood flow velocity (Vm) and evidently higher pulsatility index (PI) (p < 0.05). The levels of S100 and NSE in the experimental group increased significantly, and the level of BNDF decreased significantly (p < 0.05). In patients with hypertensive cerebrovascular disease, the level of ADPN declines; the levels of hs-CRP and sICAM-1 rise; the incidence rate of cerebrovascular complications is elevated; and there are changes in the blood lipid, cerebrovascular hemodynamic, and neurological indexes, thereby further promoting the occurrence and development of hypertensive cerebrovascular disease.
Highlights
Cardiovascular disease has become an important cause of death and disability with age
Note: the systolic and diastolic blood pressure and heart rate are all obviously increased in the experimental group compared with those in the control group (p < 0:05). ap < 0:05 vs. the control group
ADPN was negatively correlated with the incidence rate of cerebrovascular complications (p < 0:05), while high-sensitivity C-reactive protein (hs-C-reactive protein (CRP)) and soluble intercellular adhesion molecule-1 (sICAM-1) were positively correlated with the incidence rate of cerebrovascular complications (p < 0:05) (Table 8)
Summary
Cardiovascular disease has become an important cause of death and disability with age. Recent evidence suggests that hypertension is the most important risk factor for brain compartment syndrome and cerebral hemorrhage compared with other forms of stroke, indicating the role of cerebral arterial changes due to hypertension in the pathogenesis. Soluble intercellular adhesion molecule-1 (sICAM-1) has little or no expression in normal blood vessels It can participate in inflammation and adhesion reactions, leading to vasoconstriction, resulting in vascular restenosis and cardiovascular events [15]. The content of serum ADPN, hs-CRP, and sICAM-1 was determined using enzyme-linked immunosorbent assay (ELISA); the hemodynamic indexes were detected; and the neurological indexes of serum brain-derived neurotrophic factor (BNDF) and neurone-specific enolase (NSE) were determined using ELISA, hoping to provide theoretical and experimental basis for the prevention and treatment of hypertensive cerebrovascular disease
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