Abstract
Growing concern about knowledge of aerosol transport in human lungs is caused by great potential of use of inhaled pharmaceuticals. Second substantial motive for the research is an effort to minimize adverse effects of particular matter emitted by traffic and industry on human health. We created model geometry of human lungs to 7th generation of branching. This model geometry was used for fabrication of two physical models. The first one is made from thin walled transparent silicone and it allows a measurement of velocity and size of aerosol particles by Phase Doppler Anemometry (PDA). The second one is fabricated by stereolithographic method and it is designed for aerosol deposition measurements. We provided a series of measurements of aerosol transport in the transparent model and we ascertained remarkable phenomena linked with lung flow. The results are presented in brief. To gather how this phenomena affects aerosol deposition in human lungs we used the second model and we developed a technique for deposition fraction and deposition efficiency assessment.
Highlights
Research of transport and deposition of aerosols in human lungs is conducted by three different approaches
This paper deals with experimental measurement of velocity and size of aerosol particles in transparent realistic model of human airways and with experimental measurements of aerosol deposition in segmented realistic model
The model was created following way: First we created an envelope 1-5 mm thick round the initial airway geometry, and flanges were added to the parts of the model to 4th generation to provide connection of segments with screws
Summary
Research of transport and deposition of aerosols (gas borne suspensions of liquid or solid particles) in human lungs is conducted by three different approaches. I.e. in vivo, on human airway replicas, i.e. in vitro and using computational fluid dynamics (CFD), i.e. in silico. We focused on in vitro and in silico methods. This paper deals with experimental measurement of velocity and size of aerosol particles in transparent realistic model of human airways and with experimental measurements of aerosol deposition in segmented realistic model. Our results will contribute to more efficient drug delivery through inhalation route.
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