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Abstract
On these days periodontal diseases are widely distributed and diagnosed in more than 75 % of the world population and occurs in all age groups. Drugs based on medicinal plants should be considered as promising products, which have therapeutic effect with minimum adverse reactions. The aim of this work was to study the acute toxicity of new gel containing plant extract of oak bark and extract of aloe. Methods. Acute toxicity was studied in accordance with the guidelines on white nonlinear rats with 180–220 g in weight, by several steps: the study of acute toxicity of components of a new gel, the study of acute toxicity of a new gel under intragastric administration, intraperitoneal and skin administration. Results. It was established that it is not possible to determine LD 50 by intragastric administration of extract of oak bark and extract of aloe, since administration of a maximum dose of 15100 mg / kg did not cause lethality of rats. In order to confirm this assertion, in further studies the acute toxicity of extracts was studied only at a dose of 15100 mg / kg. In terms of intraperitoneally administration, LD 50 of extract of oak bark is 2580 (1930–3220) mg / kg, LD 50 of extract of aloe – 2180 (1460–2900) mg / kg. At the subsequent stages of the study during the observation for 14 days, there were no visible signs of the toxic effect of the new gel on the functional state of the animals at the maximum recommended doses: intragastric – 15100 mg / kg and skin application – 22600 mg / kg. Conclusions. The complex of the conducted studies allowed establishing that the new gel does not have a toxic effect on organs and systems of experimental animals and does not have a lethal action. Extract of oak bark and extract of aloe under conditions of intragastric administration are classified as VI class of toxicity Relatively harmless substances. In case of intraperitoneally administration, the studied extracts were classified as V class of toxicity Practically nontoxic substances. According to the study of acute toxicity, the new gel, in conditions of intragastric administration and skin application, belongs to the VI class of toxicity Relatively harmless substances
Highlights
Nowadays, dystrophic and inflammatory diseases of periodontal tissues are widespread and are diagnosed in more than 75 % of the world's population, and affect all age groups [1]
In the work Panezai J. et al (2017) [3] proved that inflammatory periodontal disease is correlated with a change in the content of 92 serum cytokines, affecting the level of chemokines, growth factors and the activity of markers enzymes for the development of destructive processes
In a study by Wang Y. (2017) [4], dystrophic-inflammatory diseases of the periodontal disease are accompanied by excessive reactive forms of oxygen produced by hyperactive neutrophils
Summary
Dystrophic and inflammatory diseases of periodontal tissues are widespread and are diagnosed in more than 75 % of the world's population, and affect all age groups [1]. Optimization of the treatment of periodontal disease is one of the important factors for restoring the health of the oral cavity, and can improve the overall health of the patient and have no negative effect on the course of concomitant systemic pathologies. Recent scientific studies on the research of the etiopathogenetic components of inflammatory diseases of the cavity of the mouth have allowed to establish that along with local lesions of the periodontal system, develop systemic pathological reactions. (2017) [4], dystrophic-inflammatory diseases of the periodontal disease are accompanied by excessive reactive forms of oxygen produced by hyperactive neutrophils. The study confirmed that the inflammatory reaction of the periodontal tissues is associated with local and systemic oxidative stress and a decrease in the activity of the antioxidant system
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