Research of the medication rules of ankylosing spondylitis based on the famous doctors' medical records

Abstract

Objective Applying the traditional Chinese medical knowledge service and sharing system, to explore the medication rules of ankylosing spondylitis in the medical records. Methods The ankylosing spondylitis medical records in the traditional chinese medical knowledge service and sharing system has been searched and 149 prescriptions were identified. The medication frequency, association rules, herbal combination and the cluster analyses were explored. Results Among the 149 prescriptions with 210 drugs, the use of high frequency drugs were Danggui, Duzhong, Weilingxian, and other medication whose frequency was more than 20 times were good at tonifying liver and kidney, activating blood circulation, clearing heat and promoting diuresis, dispelling cold and removing dampness. The high frequency of drug combinations included Sangjisheng and Gouji, Duzhong and Gouji, Baishao and Gouji, Guizhi and Baishao, Gancao and Danggui. Conclusions The treatment of ankylosing spondylitis with Chinese medicine is mainly based on tonifying liver and kidney, supplemented with drugs for warming Kidney Yang, dispelling cold and dehumidification, promoting blood circulation and removing blood stasis, clearing heat and promoting diuresis, dispelling wind and cold. Key words: Formula analysis, computer assisted; Famous doctor's experience; Spondylitis, ankylosing; Data mining; Medication regularity; The traditional Chinese medical knowledge service and sharing system