Research of the features of cardiovascular remodeling and bone tissue metabolism markers changes in women with coronary artery disease, associated with postmenopausal osteoporosis

Abstract

The coronary artery disease is the one of most urgent problems of modern cardiology as well as the problem of osteoporosis. The aim of research was to study the features of cardiovascular remodeling and bone tissue metabolism markers changes in women with coronary artery disease, associated with postmenopause osteoporosis.Methods of research. There were examined 78 women in postmenopause period with coronary artery disease (CAD): 1 group (comparison) – 19 women with CAD and normal indices of the bone tissue mineral density (BTMD); 2 group – 27 women with CAD and osteopenia; 3 group – 32 women with CAD and osteoporosis; the control group – 12 conventionally healthy women of corresponding age. With the help of ultrasound densitometry, echocardioscopy and immune-enzyme analysis the state of bone tissue mineral density, structural-functional state of heart and level of bone remodeling biomarkers were studied.Results. It was revealed, that CAD clinical course on the background of osteopenic syndrome is characterized with rise of bone remodeling markers level, increase of carotid arteries intima-media thickness, more often development of diastolic dysfunction, calcification of heart valves and big vessels, the correlations between the osteoprotegerin, osteocalcin, homocysteine levels and cardiovascular remodeling parameters were established.Conclusions. For women in postmenopause period with coronary artery disease, comorbid with osteoporosis is typical the rise of bone metabolism markers (osteoprotegerin, osteocalcin) levels and endothelial dysfunction (homocysteine) that not only reflect the state of bone tissue but also take part in cardiovascular remodeling