Research of the clinical effect and immune regulatory mechanism of red blue light combined with Niuhuang-Shangqing capsules for the moderate-severe acne

Abstract

Objective To investigate the the clinical effect and immune regulatory mechanism of red-blue light combined with Niuhuang Shangqing capsules for the moderate-severe acne. Methods A total of 180 patients with moderate to severe acne treated in People’s Hospital of Nanhai District in Foshan City from June 2014 to June 2016 were randomly divided into 2 groups with each group 90 patients. The control group was treated with red and blue light, and observation group was treated with the combination of red and blue light and Niuhuang-Shangqing capsules. The levels of SP (Substance P), IL-1 and IL-6 in peripheral blood were observed and analyzed. The recurrence rates and adverse events were observed. Results After treatment, the SP (657.4 ± 36.6 pg/ml vs. 799.9 ± 60.2 pg/ml, t=19.188), IL-1(61.8 ± 24.7 pg/L vs. 92.1 ± 23.5 pg/L, t=8.431), IL-6 (38.7 ± 10.3 pg/ml vs. 66.7 ± 14.1 pg/ml, t=12.421) of the observation group were significantly better than those of the control group (all Ps<0.01). The total effect rate of the observation group were 91.11% (82/90), which were significantly higher than 70.00% (63/90) of control group (χ2=12.804, P<0.01). Conclusions The Red-blue light combined with Niuhuang-Shangqing capsules for treating moderate-severe acne, has significant effect and can reduce the serum levels of SP, IL-1 and IL-6, with fewer adverse events and lower recurrence rates. They can be used as a safe and effective treatment of acne. Key words: Acne vulgaris; Color therapy; Niu Huang Shang Qing capsule; Adjuvants, immunologic; Comparative effectiveness research