Abstract
The aim. To conduct the research on the choice of the basis for a mild drug with a semi-solid extract of feverfew for use in dermatology.
 Materials and methods. In the study of the solubility of a semi-solid extract of feverfew (SSFE) used the method of optical microscopy using a laboratory microscope “Konus Academy”. Determination of pH and homogeneity of the studied samples was performed according to the methods described in SPhU, Vol.1. The bioavailability of the model samples was investigated by diffusion in 3 % agar gel. Colloidal stability and thermal stability were determined according to the methods of GOST 29188.3-91. Measurements of rheological parameters were performed on a rotary viscometer “MYR 3000 V 2R” (Viskotech, Spain). Determination of particle distribution was performed using a laser diffraction analyzer of particle size Mastersizer 3000.
 Results. The best results in determining the organoleptic properties, stability and degree of release of biologically active substances (BAS) showed samples prepared on emulgel and gel bases. Structural and mechanical parameters of the samples on these bases proved the presence of a non-Newtonian type of flow with plastic and thixotropic properties. When determining the distribution of SSFE particles by optical diffraction, their smaller size was determined in the sample on an emulgel basis in comparison with the gel.
 Conclusions. Emulgel loaded with specific drugs has been found effective in some topical disorders, and it is emerging as potential drug delivery system in the area of dermatology. Since emu-lgel shows enhanced spreadability, adhesion, viscosity and extrusion. Based on the obtained results, an emulsion gel base was chosen as a carrier for a semi-solid drug with SSFE
Highlights
Medicines created with the use of substances isolated from plant raw materials have been attracting attention for many decades
The aim of the research was to choose a carrier base to create a drug in the form of a semi-solid dosage form (SSDF) with a semi-solid extract of feverfew, as an active pharmaceutical ingredient with anti-inflammatory, analgesic and antimicrobial properties
The first stage of our research on the choice of base for SSDF under development was the study of the solubility of semi-solid extract of feverfew (SSFE), aimed at determining the rational way of introducing API into the base and providing the necessary biopharmaceutical requirements, the main of which is the rapid and complete release of active substances [9]
Summary
Medicines created with the use of substances isolated from plant raw materials have been attracting attention for many decades. The Ukrainian market of herbal medicines is characterized by a significant range This is due to the fact that Ukraine has always been famous for the richness of the plant world and a serious scientific base, which has a huge potential of scientists and researchers in the field of medicine and pharmacy. It provides opportunities for the isolation of biologically active substances from medicinal plant raw materials in order to create on their basis modern domestic drugs. The creation of a new pharmaceutical drug of local action on the basis of SSFE is certainly promising [3, 4]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
